Last edited by Fenos
Monday, May 11, 2020 | History

1 edition of Polypharmacology in drug discovery found in the catalog.

Polypharmacology in drug discovery

Jens-Uwe Peters

Polypharmacology in drug discovery

by Jens-Uwe Peters

  • 332 Want to read
  • 28 Currently reading

Published by Wiley in Hoboken, N.J .
Written in English

    Subjects:
  • Pharmaceutical Preparations,
  • Drug Discovery,
  • Chemistry,
  • Drug Toxicity

  • Edition Notes

    Includes bibliographical references.

    Statementedited by Jens-Uwe Peters
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL25151516M
    ISBN 109780470590904
    LC Control Number2011052324

    Although drug promiscuity (“dirty” drugs; Frantz, ) is an old observation, polypharmacology is still an emerging paradigm of drug discovery and includes drugs acting on multiple targets of unique single or multiple disease pathways (Reddy and Zhang, ).Cited by: 3. Title:Drugs Polypharmacology by In Silico Methods: New Opportunities in Drug Discovery VOLUME: 22 ISSUE: 21 Author(s):Antonino Lauria, Riccardo Bonsignore, Roberta Bartolotta, Ugo Perricone, Annamaria Martorana and Carla Gentile Affiliation:Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", Universita di Palermo, Via Archirafi 32 I Palermo, Italy.

    An important area of integration between systems biology and drug discovery is the concept of polypharmacology: the treatment of diseases by modulating more than one target. Polypharmacology for complex diseases is likely to involve multiple drugs acting on distinct targets that are part of a network regulating physiological by: This book overviews these facets of polypharmacology to help drug discovery researchers both address adverse polypharmacology and approach the discovery of polypharmacological drugs, with a third section of the book uses selected case studies to illustrate drug discovery opportunities.

    Get this from a library! Polypharmacology in drug discovery. [Jens-Uwe Peters;] -- "Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes. Addresses the important topic of polypharmacology in.   Five-year View. Polypharmacology can be used to identify new drug off-targets. This is particularly important for prediction of possible adverse effects of new drugs in development.


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Polypharmacology in drug discovery by Jens-Uwe Peters Download PDF EPUB FB2

Therefore, Polypharmacology in Drug Discovery is of utmost importance for all drug designers, medicinal chemists as well as biochemists and biologists.

The price of the book is in excellent relationship to its pages and the overall quality, in content and presentation.”―Prof. Hugo KubinyiFormat: Hardcover. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more.

Description: This book examines the emerging polypharmacological philosophy in drug discovery research (a single compound with multiple targets), challenging the current "one-drug-one-target" approach to drug discovery. It reviews the necessary considerations during safety profiling to assess the delicate balance between promiscuous drugs' therapeutic efficacies (benefits) and adverse drug.

Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and : Jens-Uwe Peters.

This chapter presents a general introduction to polypharmacology in the context of drug discovery and development. The relationship between polypharmacology and other major concepts such as polypharmacy, drug repurposing, combination of drugs, and in vivo testing is discussed. Modern applications of polypharmacology and polypharmacy in modern epigenetic and antiviral drug development Cited by: 1.

Polypharmacology: Challenges and Opportunities in Drug Discovery | Journal of Medicinal Chemistry At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a specific biological target, shares the spotlight with an emerging and alternative polypharmacology by: Polypharmacology is emerging as the next paradigm of drug discovery [7,].

Polypharmacological phenomena includes: (a) single drug acting on multiple targets of a unique disease pathway, or (b) single drug acting on multiple targets pertaining to multiple disease by:   Awareness of polypharmacology in the early stages of drug development pipelines can optimize multitargeted drug discovery and lead to more effective medicines.

This blog was written by Tonny Huang, a graduate student at the Princess Margaret Cancer : Vijay Shahani. Polypharmacology Currently, the main paradigm in drug discovery is the development of target-specific inhibitors. This also implies molecules with high-fold potency and selectivity toward one isoform.

This mainstream view has its origins in the so-called magic. Polypharmacology remains to be one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective but less toxic therapeutic agents.

Polypharmacology suggests that more effective drugs can be developed by. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and : Wiley.

Buy Polypharmacology in Drug Discovery: Read Kindle Store Reviews - Polypharmacology in Drug Discovery - Kindle edition by Jens-Uwe Peters. Professional & Technical Kindle eBooks @ At present, the legendary magic bullet, i.e., a drug with high potency and selectivity toward a specific biological target, shares the spotlight with an emerging and alternative polypharmacology approach.

Polypharmacology suggests that more effective drugs can be developed by specifically modulating multiple targets. It is generally thought that complex diseases such as cancer and central Cited by: Books.

Polypharmacology in Drug Discovery. F Innocenti. Corresponding Author. E-mail address: [email protected] Eshelman School of Pharmacy, Institute for Pharmacogenomics and Individualized Therapy, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, by: 2.

Polypharmacology offers a model for the way drug discovery must evolve to develop therapies most suited to treating currently incurable diseases. Polypharmacology in drug discovery. [Jens-Uwe Peters;] -- "Covers the two-sided nature of polypharmacology--its contribution to adverse drug reactions and.

Polypharmacology remains one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of.

(). Computational polypharmacology: a new paradigm for drug discovery. Expert Opinion on Drug Discovery: Vol. 12, No. 3, pp. Cited by: Polypharmacology can be the two-faced Janus in drug discovery and pharmacology: an adverse, off-target safety risk in some cases or a necessity for effectively treating complex diseases like.

The concept of one drug targeting multiple sites is known as polypharmacology and is gaining importance in the drug discovery process of the pharmaceutical industry. Drug molecules often interact with multiple targets, coined as polypharmacology, and the unintended drug–target interactions could cause side effects.

Polypharmacology remains one of the major challenges in drug development, and it opens novel avenues to rationally design the next generation of more effective, but less toxic, therapeutic by: Title:Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective VOLUME: 22 ISSUE: 21 Author(s):Wenjuan Zhang, Yaofei Bai, Yonghua Wang and Wei Xiao Affiliation:Department of Center of Bioinformatics, College of Life Science, Northwest A&F University, Yangling, ShaanxiChina., State Key Laboratory of New-tech for Chinese Cited by:   An essential outline of the main facets of polypharmacology in drug discovery research.

Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic : Wiley.